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  1. #1

    Anadrol (Oxymetholone, Anadrol 50, A-50, Drol, A-Bombs)

    Anadrol (commonly referred to by athletes as "A50," “Drol,” or "A-bombs") is an extremely potent oral anabolic steroid. It is a dihydrotestosterone (DHT) derivative that is 17-Alpha-Alkylated, meaning that it has been altered at the 17th carbon position to survive first pass through the liver from oral ingestion. From data compiled in standard animal assay tests, Anadrol-50 has been shown to be over three times as anabolic as testosterone, but less than half as androgenic. However, real world results in humans demonstrate that Anadrol appears to be significantly more androgenic than the animal assays suggest.

    What is Anadrol?

    Anadrol was approved as a prescription drug in the United States in the early 1960’s, and sold under the brand names Anadrol-50 (Syntex) and Androyd (Parke Davis & Co. – later discontinued). Discovered in 1959, Anadrol 50 was originally FDA approved in the early 1960’s for use in conditions where wasting and weight loss were concerns, and anabolic action was necessary. Oxymetholone was subsequently used in conditions such as geriatric debilitation, chronic underweight states, pre and post-operative preservation of lean mass, convalescence, gastrointestinal disease, osteoporosis, and general catabolic conditions. The recommended dose for such uses was usually 2.5 mg three times per day, a minute fraction of the doses bodybuilders would later use.

    By the mid-1970’s the FDA would restrict the approved uses of oxymetholone, to be limited only for the treatment of anemia characterized by deficient red blood cell (RBC) production. While the stimulation of erythropoiesis is an effect of almost all anabolic steroids, Anadrol performs the task extremely well. Anadrol has been shown to increase erythropoietin levels as much as 5 fold (1). As science and drug technology progressed, new treatments for anemia were brought forth that had more direct results with fewer side effects. Anadrol fell out of favor as an effective treatment for anemia and sales dropped. Syntex would stop production of Anadrol-50 in the United States and many other countries, in 1993. Black market prices of Anadrol climbed sharply during the mid ‘90’s as athletes feared its demise.

    In July 1997, Syntex sold all rights to Anadrol-50 in the U.S., Canada, and Mexico to Unimed Pharmaceuticals, who reintroduced Anadrol-50 to the U.S. market the next year. Upon reintroduction, Anadrol’s target market was patients with HIV/AIDS, who are commonly anemic due to infections, antiretroviral treatment drugs, or the disease itself. The other benefit to these patients with a wasting disease is that Anadrol is of course a very effective drug for promoting weight gain and thus combating wasting due to HIV. Phase II/III trials were initiated, using Anadrol for treating HIV wasting syndrome.

    Anadrol Effects on the Body

    Anadrol is considered by many to be the most powerful oral steroid regularly available. Anadrol 50 users will find that it becomes active very quickly, producing dramatic strength, weight and size gains. Novice Anadrol users can experience massive gains of up to 20-30 pounds in as little as 6 to 8 weeks of use. As previously mentioned, Anadrol is not just used for incredible gains in size. Many strength plateaus have been broken by Anadrol users as well. To the benefit of those pushing the limits of their strength, a good portion of the gains from Anadrol-50 will be from water retention. This helps provide some level of protection for connective tissues, as well as aiding muscle elasticity and contractility, which will hopefully decrease the chance of injury when lifting heavy weights.

    Although Anadrol-50 is primarily used as a bulking steroid it is often carefully used by competitive bodybuilders who are cutting, in the last couple weeks leading up to a competition in order to increase the fullness of the user’s muscles. Of course the user contemplating Anadrol use for this purpose should have taken Anadrol prior so he knows how his body reacts to the drug. It would be disastrous to use Anadrol improperly in this instance and end up looking bloated and smooth on stage.

    As one would expect, there have been many medical studies performed with Anadrol. In one 12 week Anadrol study performed with men aged 65-80, to determine whether oxymetholone increases lean body mass and skeletal muscle strength in older persons, those in the placebo group saw no change, while those in the 50mg/day group saw an average increase of 3.3kg, and those in the 100mg/day group saw an average increase of 4.2kg in lean body mass (LBM). The two oxymetholone groups also saw increases in 1 rep max of bench press and lat pull, with greater strength increases going to the larger dose group. Interestingly, the placebo group saw a decrease in strength for these two exercises. The two Anadrol groups also saw greater fat reduction than the placebo group, with the larger decrease going to the larger dose group again. The pattern of changes among the groups for LBM, upper-body strength and decreased fat mass suggested that changes might be related to dose (2).

    Anadrol was evaluated in a 30 week study and found to promote weight gain in patients with advanced HIV infection. The mean time to peak weight was 19.6 weeks in the oxymetholone group, and the average weight gain at peak was 8.2kg in the oxymetholone group, compared with an average weight loss of 1.8kg in the untreated controls. The researchers declared that, “oxymetholone was safe and promoted weight gain in cachectic patients with advanced HIV-1 infection.” (3)

    In a randomized, placebo controlled double-blind study, consisting of a treatment group that received Anadrol 50mg orally twice daily and a control group that received placebo twice daily for 24 weeks, the treatment group had significantly decreased body fat mass and increase in insulin sensitivity (4). This was merely from just walking at least one kilometer a day. Anadrol sounds like an incredible drug! And it is.

    So we know Anadrol is fantastic at increasing lean body mass, skeletal muscle strength and insulin sensitivity, as well as decreasing body fat mass, and it was deemed “safe” even when used for 30 weeks. But as with most Anabolic Androgenic Steroids (AAS), Anadrol has its drawbacks. Anadrol 50 can inhibit your body's natural hormone production and possibly negatively affect your blood lipid profile. Anadrol could cause water retention, headaches, and could also be hepatotoxic (liver toxic). And though one of the benefits touted by its original manufacturer (Syntex) is that it can be used to stimulate weight gain through increasing appetite, taking too much Anadrol may actually inhibit your appetite!

    Anadrol Side Effects

    Each user is going to be different in the side effects they may experience and how they react to a drug. Some may be predisposed to conditions that Anadrol (or other drugs) could exacerbate such as hypertension (High Blood Pressure–HBP) or others. Anadrol-50 causes notable estrogenic effects, and is often associated with reports of gynecomastia. But oxymetholone is derived from DHT so it cannot be aromatized (converted to estrogen) because it does not possess the structural capacity to do so. Aromatase Inhibitors (Aromasin, Arimidex, Forma Stanzol, etc.) then will have very little to no effect on the estrogenic activity of Anadrol.

    It has been speculated and assumed then that Anadrol is activating the progesterone receptor (PR), however evidence is available that Anadrol showed no significant binding to the PR (8). In fact, when evaluated in the menstrual cycles of 10 women, oxymetholone was shown to reduce progesterone levels by up to 80% (7). It has been speculated that Anadrol binds directly to the estrogen receptor (ER) since it cannot be converted to estrogen. But the properties of Anadrol make this a highly unlikely theory. The most plausible reason for the high apparent estrogenic activity of Anadrol is that a metabolite of the compound is binding to and activating the ER. Normally anabolic steroid metabolites are well documented and characterized, but Anadrol has so many different metabolites with further unexpected metabolites (9) that it would seem to be the best case that at least one of the metabolites would be directly estrogenic, thus causing Anadrol’s estrogenic effects. In this case prevention and/or treatment is fairly limited to SERMs. If one is quite prone to gynecomastia, the best solution would probably be to avoid Anadrol use altogether.

    The 17aa alteration, which makes it possible for Anadrol to survive first pass through your liver, also makes it taxing on your liver. How taxing? Well, if you believe the false lore posted on steroid message board forums, you would think taking Anadrol for more than 4 weeks would damage your liver and more than 6 weeks and you’d probably need a liver transplant. We have seen human studies of up to 30 weeks in length without anyone dying! One study of 24 weeks length at a 100mg daily dose had only two out of 21 patients in the treatment group experience an elevation in serum liver enzymes. After 24 weeks on 100mg of Anadrol every day, the only adverse hepatic condition was elevated liver enzymes (4). It seems apparent that side effects from Anadrol can be managed and the drug can be used safely. People are advised on message boards to limit their course of Anadrol to 4 weeks, while it seems even courses of 6-8 weeks at 50mg, twice a day could be considered safe, especially when one uses a proper liver support supplement such as TUDCA, as all those who use oral AAS should.

    While Anadrol is classified as an anabolic steroid showing low androgenic activity in assays, it does possess an undeniable androgenic effect, with possible androgenic side effects. Anadrol is already a dihydrotestosterone (DHT) based steroid, so it cannot directly convert to DHT via the 5-alpha reductase enzyme. However, oxymetholone does exhibit some tendency to convert to dihydrotestosterone in the body. One of oxymetholone’s 17α-methylated dihydrotestosterone (DHT) metabolites, Mestanolone, (17β-hydroxy-17α-methylandrost-3-one), is a potent androgen (9), which is the most likely source of the androgenic effects of Anadrol. It is not uncommon for users to report oily skin, acne, body/facial hair growth, and hair loss. These effects are usually akin to higher doses. Women should avoid Anadrol due to its potential virilizing effects which include, deepening of the voice, abnormal menstruation, hirsutism (male pattern hair growth in women), changes in skin texture, and clitoral enlargement.

    Anadrol has been shown to have some effects on plasma lipids, most notably its effect on plasma HDL-cholesterol concentrations. In the 12 week Anadrol study performed on older men (ages 65-80), who were arranged into 3 groups (placebo, 50mg/daily, 100mg/daily), there were no changes in total or LDL-cholesterol or fasting triglycerides among the three groups. But HDL-cholesterol decreased significantly in the two oxymetholone groups (−19 9 and −23 18 mg/dl) (2). A user can attempt to alleviate this by supplementing with fish oils (up to 4-5 grams a day) and a dietary supplement formulated to support cardiovascular function such as Lipid Stabil, and Talos. A good liver support supplement is also a good idea since the metabolism of estrogens mainly occurs in the liver (10).

    Anadrol Cycles

    So how much Anadrol should you use? Drugs produce a "dose-response curve" which in some cases, as with steroids like Anadrol, is a way of saying "the more you use, the more you gain." Of course these curves don’t continue to chart upwards forever. With Anadrol we see the dose- response curve reach its ceiling (flatten out) fairly quickly. When you take 50mgs of Anadrol, you'll make some good gains. When you take 100mg of Anadrol, you'll make even bigger gains. However, it has been found that a 100mg/day regimen appeared to be equally effective to a 150mg/day regimen in terms of weight gain, lean body mass, and body cell mass and was associated with less liver toxicity (6). Many who have experience with Anadrol feel that the increase from 50mg to 100mg constitutes an acceptable return in reward vs. risk, but this does not seem to be the case as dosages get over 100mg. Now, let’s see how 50mgs and 100mgs of Oxymetholone actually affect strength, when compared with each other:



    Relative (%) changes in strength are shown for the groups receiving placebo (filled bars), 50 mg/day oxymetholone (open bars), and 100 mg/day oxymetholone (gray bars). Nos. above bars represent relative change (%) from baseline to week 12 for the 1-repetition maximum tests of strength. Error bars represent 1 SE from the mean. * Significant difference from placebo, P < 0.05; †significant difference from placebo by Wilcoxon test, P < 0.02. See text for additional statistical analyses (2).

    As you can see, in this study, doubling the dose of Anadrol 50 nearly doubled the strength gains of the test subjects. When we look at changes in body composition from Oxymetholone (chart below) we can see that although the men taking 100mg (vs. the 50mg group) had more fat lost and more Lean Body Mass gained, it wasn't as dramatic as the differences in strength gains between the two groups:



    Changes in body composition are shown for the groups receiving placebo (filled bars), 50 mg of oxymetholone per day (open bars), and 100 mg per day (gray bars). Numbers above the bars represent the mean absolute changes and the error bars are 1 SE. For total lean body mass (LBM) and total fat, differences among the 3 groups were significant (P < 0.0001, one-way ANOVA). * Significant differences from placebo, P 0.001 (2).

    Most typical cycles which include Anadrol, do so by implementing it within the first 4 weeks, as a “kickstart” to a longer cycle. Remember, internet steroid board “gurus” don’t like to recommend Anadrol, or many other oral AAS for longer durations than 4 weeks. Anadrol can be used in a cycle at 100mg a day for up to 6 weeks for novices and 8 weeks for experienced users with relative safety, as long as proper Cycle Support Supplements are used in conjunction with it. Anadrol promotes quick gains in size and strength to help the user see immediate benefits in the beginning of a longer cycle usually consisting of slower acting injectable steroids like testosterone cypionate and deca-durabolin.

    Another very interesting characteristic of this compound is that Oxymetholone doesn't bind well to the androgen receptor (Relative Binding Affinity = too low to be determined) (5). It would seem then that there are a lot of non-receptor mediated effects from this steroid, making it a very potent addition to any stack, because it will not be competing for the receptor sites with the other steroids you're using.

    Following a cycle of anabolic steroids including Anadrol, it is highly recommended to implement an aggressive PCT (Post-Cycle Therapy) course of Nolvadex (and/or Clomid), and an Aromatase Inhibitor (AI) for 4 to 6 weeks of drug therapy coupled with 5-8 weeks of natural support supplements, such as liver and cardiovascular support supps, along with a testosterone booster.

    Anadrol



    Anadrol Info:

    • (Oxymetholone)
    • [17 beta-hydroxy-2-hydroxymethylene-17 alpha-methyl-5 alpha-androstan-3-one]
    • Molecular Weight: 332.482
    • Molecular Formula: C 21 H 32 O 3
    • Melting Point: 178-180C
    • Manufacturer: Syntex (Originally)
    • Release Date: 1960
    • Effective Dose: 100mgs (optimal)
    • Active Life: <16hours
    • Detection Time: up to 8 weeks
    • Androgenic: Anabolic Ratio: 45:320

    Anadrol References:

    1. Blood. 1972 Sep;40(3):353-65.
    2. Am J Physiol Endocrinol Metab 2003 Jan;284(1):E120-8.
    3. Br J Nutr. 1996 Jan;75(1):129-38.
    4. Clin Nephrol. 2009 Apr;71(4):413-22.
    5. Endocrinology. 1984 Jun;114(6):2100-6.
    6. HIV Clin Trials. 2003 May-Jun;4(3):150-63.
    7. Am J Obstet Gynecol. 1975 Jan 1;121(1):121-6.
    8. Helv Med Acta. 1960 Dec;27:479-503.
    9. J Steroid Biochem Mol Biol. 1992 Apr;42(2):229-42.
    10. Cancer Lett. 2005 Sep 28;227(2):115-24. Epub 2004 Nov 19.
    Last edited by ceo; 03-26-2015 at 12:38 PM.


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  2. #2
    Anadrol (Oxymetholone)

    by Bill Roberts – Anadrol (oxymetholone) is most likely second only to Dianabol (methandrostenolone) as a bodybuilding anabolic steroid. Additionally, it has had considerable medical importance particularly for treatment of anemia, and more recently to help maintain lean body mass in HIV-compromised patients. While many have the subjective opinion that Anadrol is a harsh drug in terms of side effects, medical findings and the findings of many athletes are quite different.

    Stacking Anadrol with Other Steroids

    An interesting further question concerns combination of Anadrol with other anabolic steroids. For exmaple, adding Anadrol to 50 mg/day of Dianabol gives little added benefit to a steroid cycle; in contrast, adding Anadrol to 50-100 mg/day trenbolone acetate or 60-80 mg/day Anavar (oxandrolone) gives dramatic improvement. In this its stacking behavior is similar to that of Dianabol, but not to that of trenbolone. Likely this is because unlike trenbolone, oxymetholone does not bind strongly to the androgen receptor, and most of its anabolic effect is likely not genomically mediated via the AR.

    Anadrol Side Effects

    With regard to harsh side effects sometimes perceived in bodybuilding, this principally or only occurs when estrogen levels are elevated. While oxymetholone does not itself aromatize and does not have estrogenic activity, it may be that it can interfere with estrogen metabolism. Whether that it is the cause of the problem or not, keeping estradiol levels under control keeps Anadrol similar in side effects to other oral anabolic steroids. Estradiol levels may be kept under control either by using an aromatase inhibitor such as letrozole or Arimidex, or by limiting use of aromatizing steroids such as testosterone.

    Anadrol and Liver Toxicity

    The principal side effect of concern is liver toxicity, as is the case for all alkylated oral anabolic steroids. This may be addressed simply by limiting duration of use to 6-8 weeks, and allowing suitable time off of the drug after each period of use. Because the liver regenerates quickly, a time of even half the period of use is often sufficient. However, allowing an equal amount of time is more conservative.

    Per milligram, Anadrol appears less liver toxic than any other alkylated anabolic steroid, but per amount of anabolic effect, the ratio of toxicity to anabolic effect seems similar.

    Other side effects of concern are the same as with other anabolic steroids in general, including potential increase in blood pressure and/or hematocrit, worsening of blood lipid profile, prostate enlargement which may be temporary, and possible promotion of acne and/or male pattern baldness, if having the gene for male pattern baldness.

    Anadrol Dosages

    Typical usage is 50-150 mg/day. In some cases larger doses such as 300 mg/day are used, but when suitably stacked with one or more other anabolic steroids, often there is little further benefit from exceeding 150 mg/day.

    Anadrol and Women

    While it’s common for bodybuilders to suspect that Anadrol would be an even riskier choice for use by women than most anabolic steroids, actually the reverse is true. Medically, once per day dosing of 50 mg/day over extended periods has shown only a moderate rate of virilization problems. The same certainly cannot be said of Anavar, Dianabol, or Winstrol (stanozolol.) While not necessarily sufficient for high level female bodybuilding competition by today’s standards, such a dose actually is considerably more than needed by most women for excellent results in adding muscle, losing fat, and generally improving their physiques. Half this dose — 25 mg/day, preferably taken as divided doses — is very effective and is so far as I know the lowest-risk way to obtain this degree of benefit from anabolic steroids.

    Even 12.5 mg/day in divided doses can be remarkably effective.

    Anadrol and Virilization

    This is not to say, however, that at even these reduced doses there is no risk of virilization. As seen from the fact that some women with time develop facial hair and voice hoarseness simply from their natural androgen levels, it’s possible for an individual woman to be on the threshold of virilization in the first place. In these cases, any added androgen, even oral DHEA supplementation, can trigger virilizing side effects. So it must be understood that risk does exist.

    Anadrol Guidelines

    Briefly: Using Anadrol, or Dianabol, in combination with injectable anabolic steroids is one of the most effective ways to improve a steroid cycle. It is not necessary to use both Dianabol and Anadrol simultaneously: usually only one or the other is chosen. With proper care, side effects are generally very tolerable and pose a health risk low enough to generally be acceptable by bodybuilding standards.

    Oxymetholone is the name of the active ingredient in Anadrol. Anadrol is a registered trademark of Unimed Pharmaceuticals in the United States and/or other countries.



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